6S1F
Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Receptor-interacting serine/threonine-protein kinase 2 | polymer | 317 | 36385.9 | 4 | UniProt (O43353) Pfam (PF07714) In PDB | Homo sapiens (Human) | CARD-containing interleukin-1 beta-converting enzyme-associated kinase,CARD-containing IL-1 beta ICE-kinase,RIP-like-interacting CLARP kinase,Receptor-interacting protein 2,RIP-2,Tyrosine-protein kinase RIPK2 |
| 2 | A, B, C, D | ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide | non-polymer | 453.6 | 4 | Chemie (KRE) | |||
| 3 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 317 (UniProt: O43353)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 145543.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1814.2 | |
| All* | Total formula weight | 147357.6 |
