6S0B

Crystal Structure of Properdin in complex with the CTC domain of C3/C3b

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Properdin	polymer	225	25058.5	1	UniProt (P27918) Pfam (PF00090) Pfam (PF22195)	Homo sapiens (Human)	Complement factor P
2	B (B)	Properdin	polymer	110	11891.4	1	UniProt (P27918) Pfam (PF18487) Pfam (PF00090)	Homo sapiens (Human)	Complement factor P
3	C (C)	Complement C3	polymer	149	17275.3	1	UniProt (P01024) Pfam (PF01759)	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
4	D (D)	beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose	branched		326.3	1	In PDB GlyTouCan (G36855WW)
5	E, F, G, H, I... (A, B)	alpha-D-mannopyranose	non-polymer		180.2	8	Chemie (MAN)
6	J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	N, O, P (A, B, C)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 256 - 469 (UniProt: P27918)

PDB	External Database	Details
Gly 254	-	expression tag
Ser 255	-	expression tag
Ala 470	-	expression tag
Ala 471	-	expression tag
Ala 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag

B: 26 - 132 (UniProt: P27918)

PDB	External Database	Details
Ala 133	-	expression tag
Ala 134	-	expression tag
Ala 135	-	expression tag

C: 1517 - 1663 (UniProt: P01024)

PDB	External Database	Details
Gly 1515	-	expression tag
Ser 1516	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	54225.1
Branched	Number of molecules	1
	Total formula weight	326.3
Non-Polymers*	Number of molecules	9
	Total formula weight	1662.5
All*	Total formula weight	56213.9

*Water molecules are not included.