6RZ4

Crystal structure of cysteinyl leukotriene receptor 1 in complex with pranlukast

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1	polymer	423	47927.1	1	UniProt (Q9Y271) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB	Homo sapiens (Human)	CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81,Cytochrome b-562,CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81
2	A	pranlukast	non-polymer		481.5	1	Chemie (KNT)
3	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	A	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	9	Chemie (OLC)
5	A	OLEIC ACID	non-polymer		282.5	1	Chemie (OLA)
6		water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 1 - 222 (UniProt: Q9Y271)

PDB	External Database	Details
Gly -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag

A: 1001 - 1105 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	conflict
Ile 1102	His 124	conflict
Leu 1106	-	linker
Ser	-	linker
Gly	-	linker

A: null - 311 (UniProt: Q9Y271)

PDB	External Database	Details
Ser 1000	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	47927.1
Non-Polymers*	Number of molecules	12
	Total formula weight	3995.8
All*	Total formula weight	51922.9

*Water molecules are not included.