6RXQ
Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after soaking
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | NAD-dependent protein deacylase | polymer | 254 | 28054.7 | 4 | UniProt (P75960) Pfam (PF02146) In PDB | Escherichia coli (strain K12) | Regulatory protein SIR2 homolog |
2 | E, F, G, H | Histone H4 | polymer | 11 | 1269.6 | 4 | UniProt (P02309) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | |
3 | E, F, G, H | [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | non-polymer | 613.4 | 4 | Chemie (KMQ) | |||
4 | water | water | 18.0 | 582 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 40 - 279 (UniProt: P75960)
PDB | External Database | Details |
---|---|---|
Met -14 | - | initiating methionine |
Gly -13 | - | expression tag |
Ser -12 | - | expression tag |
Ser -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Ser -4 | - | expression tag |
Gln -3 | - | expression tag |
Asp -2 | - | expression tag |
Pro -1 | - | expression tag |
Gly 76 | Ala 76 | engineered mutation |
Cys 131 | Ile 131 | engineered mutation |
Ala 161 | Val 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 117297.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2453.6 | |
All* | Total formula weight | 119750.6 |