6RXO

Crystal structure of CobB Ac2 (A76G, I131C, V162A) in complex with H4K16-Buturyl peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NAD-dependent protein deacylase	polymer	254	28054.7	2	UniProt (P75960) Pfam (PF02146) In PDB	Escherichia coli (strain K12)	Regulatory protein SIR2 homolog
2	C, D	Histone H4	polymer	11	1338.7	2	UniProt (P02309) In PDB	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A, B: 40 - 279 (UniProt: P75960)

PDB	External Database	Details
Met -14	-	initiating methionine
Gly -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Ser -4	-	expression tag
Gln -3	-	expression tag
Asp -2	-	expression tag
Pro -1	-	expression tag
Gly 76	Ala 76	engineered mutation
Cys 131	Ile 131	engineered mutation
Ala 161	Val 161	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	58786.6
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	58917.5

*Water molecules are not included.