6RWO

SIVrcm intasome (Q148H/G140S) in complex with bictegravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E, F, G... (A, E, N, L, K...)	Pol protein	polymer	290	32772.2	12	UniProt (E1ANT8) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552)	Simian immunodeficiency virus
2	B, J (Q, S)	DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3')	polymer	33	10134.5	2		Simian immunodeficiency virus
3	C, K (W, T)	DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3')	polymer	30	9224.0	2		Simian immunodeficiency virus
4	DA, EA, FA, Q, V... (M, C, B, A, E...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
5	R, Z (A, I)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	AA, S (I, A)	Bictegravir	non-polymer		449.4	2	Chemie (KLQ)
7	BA, CA, T, U (I, A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
8	GA, HA (A, I)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

A, E, N, L, K, J, I, M, F, D, C, B: 1 - 289 (UniProt: E1ANT8)

PDB	External Database	Details
Gly 0	-	expression tag
Asp 119	Ala 853	engineered mutation
Ser 140	Gly 874	engineered mutation
His 148	Gln 882	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	431983.7
Non-Polymers*	Number of molecules	16
	Total formula weight	1590.2
All*	Total formula weight	433573.9

*Water molecules are not included.