6RVD
Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein patched homolog 1 | polymer | 1447 | 160714.4 | 2 | UniProt (Q13635) Pfam (PF02460) | Homo sapiens (Human) | PTC1 |
| 2 | C (C) | Sonic hedgehog protein | polymer | 174 | 19594.0 | 1 | UniProt (Q15465) Pfam (PF01085) | Homo sapiens (Human) | SHH,HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC |
| 3 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | E, K, L, P (A, B, C) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 5 | F, G, H, I, J... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 6 | O (C) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
| 7 | Q (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | R, S (C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 341022.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3497.1 | |
| All* | Total formula weight | 344944.3 |
