6RVC

Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Protein patched homolog 1	polymer	261	30659.3	3	UniProt (Q13635) Pfam (PF02460) In PDB	Homo sapiens (Human)	PTC1
2	D, E, F	Nanobody NB75	polymer	134	14820.2	3		Lama glama
3	A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	C	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5		water	water		18.0	202	Chemie (HOH)

Sequence modifications

A, B, C: 772 - 1023 (UniProt: Q13635)

PDB	External Database	Details
Glu 763	-	expression tag
Thr 764	-	expression tag
Gly 765	-	expression tag
His 766	-	expression tag
His 767	-	expression tag
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	136438.4
Non-Polymers*	Number of molecules	3
	Total formula weight	538.5
All*	Total formula weight	136976.9

*Water molecules are not included.