6RV3
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium channel subfamily K member 3 | polymer | 264 | 30117.0 | 4 | UniProt (O14649) Pfam (PF07885) | Homo sapiens (Human) | Acid-sensitive potassium channel protein TASK-1,TWIK-related acid-sensitive K(+) channel 1,Two pore potassium channel KT3.1,Two pore K(+) channel KT3.1 |
| 2 | E, F, G, L, Q... (A, C) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 3 | H, I, N, O, U... (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 7 | Chemie (Y01) | |||
| 4 | AA, J, P, W (D, A, B, C) | DECYL-BETA-D-MALTOPYRANOSIDE | non-polymer | 482.6 | 4 | Chemie (DMU) | |||
| 5 | BA, K, X (D, A) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 3 | Chemie (PC1) | |||
| 6 | M, V (A, C) | [4-[[2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(2-fluorophenyl)methanone | non-polymer | 493.4 | 2 | Chemie (KKQ) | |||
| 7 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 259 (UniProt: O14649)
| PDB | External Database | Details |
|---|---|---|
| Asn 260 | - | expression tag |
| Leu 261 | - | expression tag |
| Tyr 262 | - | expression tag |
| Phe 263 | - | expression tag |
| Gln 264 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 120468.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 9007.3 | |
| All* | Total formula weight | 129475.3 |
