6RPG

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Programmed cell death 1 ligand 1	polymer	128	14678.8	2	UniProt (Q9NZQ7) Pfam (PF07686) In PDB	Homo sapiens (Human)	Programmed death ligand 1,B7 homolog 1,B7-H1
2	B	~{N}-[2-[[4-[[3-[3-[[4-[(2-acetamidoethylamino)methyl]-5-[(5-cyanopyridin-3-yl)methoxy]-2-methyl-phenoxy]methyl]-2-methyl-phenyl]-2-methyl-phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]-5-methyl-phenyl]methylamino]ethyl]ethanamide	non-polymer		915.1	1	Chemie (KDW)
3		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B: 18 - 134 (UniProt: Q9NZQ7)

PDB	External Database	Details
Ala 135	-	expression tag
Ala 136	-	expression tag
Ala 137	-	expression tag
Leu 138	-	expression tag
Glu 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29357.5
Non-Polymers*	Number of molecules	1
	Total formula weight	915.1
All*	Total formula weight	30272.6

*Water molecules are not included.