6ROT
Thrombin in complex with MI2105
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Prothrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B (H) | Prothrombin | polymer | 253 | 29208.6 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | C (A) | Hirudin variant-2 | polymer | 12 | 1548.6 | 1 | UniProt (P09945) | Hirudo medicinalis | |
| 4 | D (H) | (2~{S})-~{N}-[[5-chloranyl-2-(hydroxymethyl)phenyl]methyl]-1-[2-[(phenylmethyl)sulfonylamino]ethanoyl]pyrrolidine-2-carboxamide | non-polymer | 480.0 | 1 | Chemie (KDQ) | |||
| 5 | E (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F (H) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | G, J, K (H) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 8 | H, I (H) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 9 | L, M, N (L, H, A) | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
H: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| - | Thr 512 | deletion |
| - | Ala 513 | deletion |
| - | Asn 514 | deletion |
| - | Val 515 | deletion |
| - | Gly 516 | deletion |
| - | Lys 517 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 34853.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1076.5 | |
| All* | Total formula weight | 35930.2 |
