6RMY
Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Carbonic anhydrase 2 | polymer | 260 | 29287.1 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | non-polymer | 444.5 | 1 | Chemie (V14) | |||
| 4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | A | BICINE | non-polymer | 163.2 | 1 | Chemie (BCN) | |||
| 6 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 7 | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Val 200 | Thr 199 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29287.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 946.4 | |
| All* | Total formula weight | 30233.5 |
