6RME
Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G (A, G) | IMP-specific 5'-nucleotidase, putative | polymer | 384 | 44955.8 | 2 | UniProt (A0A144A134) Pfam (PF06437) | Plasmodium falciparum (isolate 3D7) | |
| 2 | B, D (B, D) | IMP-specific 5'-nucleotidase, putative | polymer | 385 | 45084.0 | 2 | UniProt (A0A144A134) Pfam (PF06437) | Plasmodium falciparum (isolate 3D7) | |
| 3 | C (C) | IMP-specific 5'-nucleotidase, putative | polymer | 394 | 46116.2 | 1 | UniProt (A0A144A134) Pfam (PF06437) | Plasmodium falciparum (isolate 3D7) | |
| 4 | E, H (E, H) | IMP-specific 5'-nucleotidase, putative | polymer | 386 | 45198.1 | 2 | UniProt (A0A144A134) Pfam (PF06437) | Plasmodium falciparum (isolate 3D7) | |
| 5 | F (F) | IMP-specific 5'-nucleotidase, putative | polymer | 388 | 45444.4 | 1 | UniProt (A0A144A134) Pfam (PF06437) | Plasmodium falciparum (isolate 3D7) | |
| 6 | I, K, M, O, R... (A, B, C, D, E...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) | |||
| 7 | J, L, N, P, S... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) PubChem (888) | |||
| 8 | Q, T (D, E) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 9 | AA, BA, CA (B, C, F) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, G: 47 - 430 (UniProt: A0A144A134)
B, D: 46 - 430 (UniProt: A0A144A134)
C: 38 - 431 (UniProt: A0A144A134)
E, H: 46 - 431 (UniProt: A0A144A134)
F: 45 - 431 (UniProt: A0A144A134)
| PDB | External Database | Details |
|---|---|---|
| Asn 172 | Asp 172 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 172 | Asp 172 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 172 | Asp 172 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 172 | Asp 172 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Phe 44 | - | expression tag |
| Asn 172 | Asp 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 362036.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3164.3 | |
| All* | Total formula weight | 365200.5 |
