6RFN
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1018
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphodiesterase | polymer | 360 | 40623.3 | 2 | UniProt (Q8WQX9) Pfam (PF00233) | Trypanosoma brucei | |
| 2 | C, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, M (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 5 | G, H, I, N (A, B) | GUANIDINE | non-polymer | 59.1 | 4 | Chemie (GAI) | |||
| 6 | J, O, P (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | K, Q (A, B) | 3-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(3-methoxyphenyl)prop-2-ynamide | non-polymer | 471.5 | 2 | Chemie (K3W) | |||
| 8 | R, S (A, B) | water | water | 18.0 | 339 | Chemie (HOH) |
Sequence modifications
A, B: 565 - 918 (UniProt: Q8WQX9)
| PDB | External Database | Details |
|---|---|---|
| Gly 559 | - | expression tag |
| Ser 560 | - | expression tag |
| His 561 | - | expression tag |
| Met 562 | - | expression tag |
| Ala 563 | - | expression tag |
| Ser 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81246.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1727.1 | |
| All* | Total formula weight | 82973.8 |
