6RD0
Human MMP12 catalytic domain in complex with AP280
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Macrophage metalloelastase | polymer | 159 | 17615.7 | 1 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (Human) | MME,Macrophage elastase,hME,Matrix metalloproteinase-12,MMP-12 |
2 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
4 | A | ~{N}-[2-(1~{H}-indol-3-yl)ethyl]-2-(3-oxidanyl-2-oxidanylidene-pyridin-1-yl)ethanamide | non-polymer | 311.3 | 1 | Chemie (K0Q) | |||
5 | A | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 1 | Chemie (HAE) | |||
6 | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDB | External Database | Details |
---|---|---|
Met 105 | - | initiating methionine |
Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 17615.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 637.5 | |
All* | Total formula weight | 18253.1 |