6RAI

Heterodimeric ABC exporter TmrAB in ATP-bound outward-facing occluded conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Multidrug resistance ABC transporter ATP-binding and permease protein	polymer	623	70663.8	1	UniProt (Q72J05) Pfam (PF00664) Pfam (PF00005)	Thermus thermophilus
2	B (B)	Multidrug resistance ABC transporter ATP-binding and permease protein	polymer	578	64634.5	1	UniProt (Q72J04) Pfam (PF00664) Pfam (PF00005)	Thermus thermophilus
3	C (C)	Nanobody Nb9F10	polymer	136	14594.4	1		Vicugna pacos
4	D, F (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
5	E, G (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	H, I (A, B)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 1 - 600 (UniProt: Q72J05)

PDB	External Database	Details
Gln 523	Glu 523	engineered mutation
Lys 601	-	expression tag
Leu 602	-	expression tag
Gly 603	-	expression tag
Gly 604	-	expression tag
Gly 605	-	expression tag
Gly 606	-	expression tag
Glu 607	-	expression tag
Asn 608	-	expression tag
Leu 609	-	expression tag
Tyr 610	-	expression tag
Phe 611	-	expression tag
Gln 612	-	expression tag
Gly 613	-	expression tag
His 614	-	expression tag
His 615	-	expression tag
His 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	149892.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	150955.6

*Water molecules are not included.