6RAA
CLK1 Kinase domain with bound imidazopyridin inhibitor TP003
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | B (A) | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | non-polymer | 482.6 | 1 | Chemie (JWN) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
| Met 147 | - | expression tag |
| Ala 432 | Arg 432 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39581.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.6 | |
| All* | Total formula weight | 40126.2 |
