Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6R7I

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACOP9 signalosome complex subunit 1polymer46252494.11UniProt (Q13098)
Pfam (PF10602)
Pfam (PF01399)
Pfam (PF21151)
In PDB		Homo sapiens (Human)Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH
2BCOP9 signalosome complex subunit 2polymer44351664.61UniProt (P61201)
Pfam (PF01399)
In PDB		Homo sapiens (Human)Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15
3CCOP9 signalosome complex subunit 3polymer40145606.51UniProt (Q9UNS2)
Pfam (PF22788)
Pfam (PF01399)
Pfam (PF21215)
In PDB		Homo sapiens (Human)Signalosome subunit 3,JAB1-containing signalosome subunit 3
4DCOP9 signalosome complex subunit 4polymer40746479.91UniProt (Q9BT78)
Pfam (PF18420)
Pfam (PF22241)
Pfam (PF01399)
In PDB		Homo sapiens (Human)Signalosome subunit 4,JAB1-containing signalosome subunit 4
5ECOP9 signalosome complex subunit 5polymer33437621.71UniProt (Q92905)
Pfam (PF01398)
Pfam (PF18323)
In PDB		Homo sapiens (Human)Signalosome subunit 5,Jun activation domain-binding protein 1
6FCOP9 signalosome complex subunit 6polymer32736203.41UniProt (Q7L5N1)
Pfam (PF01398)
Pfam (PF13012)
In PDB		Homo sapiens (Human)Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP
7GCOP9 signalosome complex subunit 7bpolymer21523944.41UniProt (Q9H9Q2)
Pfam (PF22061)
Pfam (PF01399)
Pfam (PF18392)
In PDB		Homo sapiens (Human)Signalosome subunit 7b,JAB1-containing signalosome subunit 7b
8HCOP9 signalosome complex subunit 8polymer20923245.51UniProt (Q99627)
Pfam (PF10075)
In PDB		Homo sapiens (Human)Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8
9NNEDD8polymer788876.81Pfam (PF00240)
UniProt (by SIFTS) (Q15843)
In PDB		Homo sapiens (Human)
10OCullin-2polymer74587098.91UniProt (Q13617)
Pfam (PF00888)
Pfam (PF10557)
In PDB		Homo sapiens (Human)CUL-2
11PElongin-Bpolymer10611973.61UniProt (Q15370)
Pfam (PF00240)
In PDB		Homo sapiens (Human)EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
12QElongin-Cpolymer9911338.81Pfam (PF03931)
UniProt (by SIFTS) (Q03071)
In PDB		Homo sapiens
13RE3 ubiquitin-protein ligase RBX1polymer8510021.61Pfam (PF12678)
UniProt (by SIFTS) (P62877)
In PDB		Homo sapiens
14E, RZINC IONnon-polymer65.44Chemie (ZN)
15waterwater18.0169Chemie (HOH)
Sequence modifications
A: 77 - 527 (UniProt: Q13098)
PDBExternal DatabaseDetails
Lys 70-expression tag
Val 71-expression tag
Tyr 72-expression tag
Ile 73-expression tag
Glu 74-expression tag
Lys 75-expression tag
Asp 76-expression tag
D: 1 - 406 (UniProt: Q9BT78)
PDBExternal DatabaseDetails
Arg 0-expression tag
G: 1 - 215 (UniProt: Q9H9Q2)
PDBExternal DatabaseDetails
Leu 167Ile 167conflict
Ser 168Asn 168conflict
Ala 169Asn 169conflict
Ala 171Val 171conflict
Arg 172Lys 172conflict
Gln 175His 175conflict
Val 179Asp 179conflict
Val 183Ala 183conflict
Ser 186Leu 186conflict
Glu 190Gln 190conflict
Ser 193Leu 193conflict
His 198Tyr 198conflict
Gln 201Asn 201conflict
Gln 202His 202conflict
Leu 203Asn 203conflict
Gly 204Arg 204conflict
Leu 205Thr 205conflict
Lys 206Gln 206conflict
Ile 209Val 209conflict
Ser 211Ala 211conflict
Ala 214Thr 214conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains13
Total formula weight446569.9
Non-Polymers*Number of molecules4
Total formula weight261.6
All*Total formula weight446831.5
*Water molecules are not included.

224201

PDB entries from 2024-08-28

PDB statisticsPDBj update infoContact PDBjnumon