6R7F
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | COP9 signalosome complex subunit 1 | polymer | 433 | 49253.5 | 1 | UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151) In PDB | Homo sapiens (Human) | Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH |
| 2 | B | COP9 signalosome complex subunit 2 | polymer | 443 | 51664.6 | 1 | UniProt (P61201) Pfam (PF01399) In PDB | Homo sapiens (Human) | Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15 |
| 3 | C | COP9 signalosome complex subunit 3 | polymer | 403 | 45808.8 | 1 | UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215) In PDB | Homo sapiens (Human) | Signalosome subunit 3,JAB1-containing signalosome subunit 3 |
| 4 | D | COP9 signalosome complex subunit 4 | polymer | 406 | 46322.7 | 1 | UniProt (Q9BT78) Pfam (PF18420) Pfam (PF22241) Pfam (PF01399) In PDB | Homo sapiens (Human) | Signalosome subunit 4,JAB1-containing signalosome subunit 4 |
| 5 | E | COP9 signalosome complex subunit 5 | polymer | 311 | 35184.1 | 1 | UniProt (Q92905) Pfam (PF01398) Pfam (PF18323) In PDB | Homo sapiens (Human) | Signalosome subunit 5,Jun activation domain-binding protein 1 |
| 6 | F | COP9 signalosome complex subunit 6 | polymer | 288 | 32507.2 | 1 | UniProt (Q7L5N1) Pfam (PF01398) Pfam (PF13012) In PDB | Homo sapiens (Human) | Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP |
| 7 | H | COP9 signalosome complex subunit 8 | polymer | 209 | 23245.5 | 1 | UniProt (Q99627) Pfam (PF10075) In PDB | Homo sapiens (Human) | Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8 |
| 8 | G | COP9 signalosome complex subunit 7b | polymer | 208 | 23429.7 | 1 | UniProt (Q9H9Q2) Pfam (PF22061) Pfam (PF01399) Pfam (PF18392) In PDB | Homo sapiens (Human) | Signalosome subunit 7b,JAB1-containing signalosome subunit 7b |
| 9 | V | von Hippel-Lindau disease tumor suppressor | polymer | 160 | 18558.2 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | Homo sapiens (Human) | Protein G7,pVHL |
| 10 | P | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 11 | Q | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 12 | O | Cullin-2 | polymer | 745 | 87098.9 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens (Human) | CUL-2 |
| 13 | R | E3 ubiquitin-protein ligase RBX1 | polymer | 90 | 10655.2 | 1 | Pfam (PF12678) UniProt (by SIFTS) (P62877) In PDB | Homo sapiens | |
| 14 | N | NEDD8 | polymer | 76 | 8574.0 | 1 | UniProt (Q15843) Pfam (PF00240) In PDB | Homo sapiens (Human) | Neddylin,Neural precursor cell expressed developmentally down-regulated protein 8,NEDD-8,Ubiquitin-like protein Nedd8 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 457935.3 | |
| All* | Total formula weight | 457935.3 |
