6R6P
Structure of XBP1u-paused ribosome nascent chain complex (rotated state)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (5) | 28S ribosomal RNA | polymer | 3662 | 1186579.5 | 1 | Oryctolagus cuniculus | ||
| 2 | B (7) | 5S ribosomal RNA | polymer | 120 | 38691.9 | 1 | Oryctolagus cuniculus | ||
| 3 | C (8) | 5.8S ribosomal RNA | polymer | 156 | 50143.6 | 1 | Oryctolagus cuniculus | ||
| 4 | D (A) | uL2 | polymer | 244 | 26570.1 | 1 | UniProt (G1TT27) Pfam (PF03947) Pfam (PF00181) | Oryctolagus cuniculus (Rabbit) | |
| 5 | E (B) | uL3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (Rabbit) | |
| 6 | F (C) | uL4 | polymer | 362 | 41101.4 | 1 | UniProt (G1SVW5) Pfam (PF00573) Pfam (PF14374) | Oryctolagus cuniculus (Rabbit) | |
| 7 | G (D) | 60S ribosomal protein L5 | polymer | 292 | 34006.3 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (Rabbit) | |
| 8 | H (E) | 60S ribosomal protein L6 | polymer | 248 | 28529.8 | 1 | UniProt (G1TG04) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (Rabbit) | |
| 9 | I (F) | uL30 | polymer | 225 | 26662.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) | Oryctolagus cuniculus (Rabbit) | |
| 10 | J (G) | eL8 | polymer | 241 | 27480.6 | 1 | UniProt (G1STW0) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 11 | K (H) | uL6 | polymer | 190 | 21627.2 | 1 | UniProt (G1TX33) Pfam (PF00347) UniProt (by SIFTS) (G1SWI6) | Oryctolagus cuniculus (Rabbit) | |
| 12 | L (I) | Ribosomal protein L10 (Predicted) | polymer | 213 | 24511.9 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (Rabbit) | |
| 13 | M (J) | uL5 | polymer | 169 | 19270.3 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (Rabbit) | |
| 14 | N (L) | 60S ribosomal protein L13 | polymer | 210 | 24216.5 | 1 | UniProt (G1TPV0) | Oryctolagus cuniculus (Rabbit) | |
| 15 | O (M) | Ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (U3KNW6) Pfam (PF01929) UniProt (by SIFTS) (G1SZ12) | Oryctolagus cuniculus (Rabbit) | |
| 16 | P (N) | Ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (Rabbit) | |
| 17 | Q (O) | uL13 | polymer | 199 | 23248.9 | 1 | Oryctolagus cuniculus | ||
| 18 | R (P) | uL22 | polymer | 153 | 17758.7 | 1 | UniProt (G1TVT6) Pfam (PF00237) UniProt (by SIFTS) (G1SCJ6) | Oryctolagus cuniculus (Rabbit) | |
| 19 | S (Q) | eL18 | polymer | 187 | 21457.4 | 1 | UniProt (G1TX70) Pfam (PF17135) | Oryctolagus cuniculus (Rabbit) | |
| 20 | T (R) | eL19 | polymer | 180 | 21613.0 | 1 | Oryctolagus cuniculus | ||
| 21 | U (S) | eL20 | polymer | 175 | 20696.4 | 1 | Oryctolagus cuniculus | ||
| 22 | V (T) | eL21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (Rabbit) | |
| 23 | W (U) | Ribosomal protein L22 | polymer | 99 | 11481.2 | 1 | UniProt (G1TSG1) Pfam (PF01776) | Oryctolagus cuniculus (Rabbit) | |
| 24 | X (V) | uL14 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (Rabbit) | |
| 25 | Y (W) | Ribosomal protein L24 | polymer | 63 | 7512.8 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (Rabbit) | |
| 26 | Z (X) | uL23 | polymer | 119 | 13856.4 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (Rabbit) | |
| 27 | AA (Y) | Ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (Rabbit) | |
| 28 | BA (Z) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (Rabbit) | |
| 29 | CA (a) | uL15 | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (Rabbit) | |
| 30 | DA (b) | 60S ribosomal protein L29 | polymer | 75 | 8706.3 | 1 | UniProt (G1TN82) Pfam (PF01779) UniProt (by SIFTS) (G1SGR6) | Oryctolagus cuniculus (Rabbit) | |
| 31 | EA (c) | eL30 | polymer | 94 | 10496.4 | 1 | Oryctolagus cuniculus | ||
| 32 | FA (d) | eL31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (Rabbit) | |
| 33 | GA (e) | eL32 | polymer | 128 | 15022.0 | 1 | UniProt (G1TUN8) Pfam (PF01655) | Oryctolagus cuniculus (Rabbit) | |
| 34 | HA (f) | eL33 | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (Rabbit) | |
| 35 | IA (g) | eL34 | polymer | 114 | 12994.6 | 1 | UniProt (G1U945) Pfam (PF01199) UniProt (by SIFTS) (G1TXG5) | Oryctolagus cuniculus (Rabbit) | |
| 36 | JA (h) | uL29 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (Rabbit) | |
| 37 | KA (i) | 60S ribosomal protein L36 | polymer | 102 | 11888.4 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (Rabbit) | |
| 38 | LA (j) | Ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (Rabbit) | |
| 39 | MA (k) | eL38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus | ||
| 40 | NA (l) | ribosomal protein eL39 | polymer | 50 | 6295.6 | 1 | UniProt (G1SYU7) Pfam (PF00832) | Oryctolagus cuniculus (Rabbit) | |
| 41 | OA (m) | eL40 | polymer | 52 | 6199.6 | 1 | Oryctolagus cuniculus | ||
| 42 | PA (n) | 60s ribosomal protein l41 | polymer | 23 | 3213.1 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (Rabbit) | |
| 43 | QA (o) | eL42 | polymer | 104 | 12198.6 | 1 | UniProt (G1T040) Pfam (PF00935) | Oryctolagus cuniculus (Rabbit) | |
| 44 | RA (p) | ribosomal protein eL43 | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (Rabbit) | |
| 45 | SA (r) | eL28 | polymer | 125 | 14319.8 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (Rabbit) | |
| 46 | TA (s) | 60S acidic ribosomal protein P0 | polymer | 198 | 21747.3 | 1 | UniProt (G1U6N2) | Oryctolagus cuniculus (Rabbit) | |
| 47 | UA (t) | Ribosomal protein L12 | polymer | 163 | 17689.5 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (Rabbit) | |
| 48 | VA (1) | X-box-binding protein 1 | polymer | 24 | 2895.4 | 1 | UniProt (P17861) | Homo sapiens (Human) | XBP-1,Tax-responsive element-binding protein 5,TREB-5 |
| 49 | WA (2) | A/P-tRNA | polymer | 76 | 24414.5 | 1 | Saccharomyces cerevisiae | ||
| 50 | XA (3) | P/E-tRNA | polymer | 75 | 24148.4 | 1 | Saccharomyces cerevisiae | ||
| 51 | YA (K) | 18S rRNA | polymer | 1698 | 548024.2 | 1 | Oryctolagus cuniculus | ||
| 52 | ZA (q) | uS2 | polymer | 217 | 24361.9 | 1 | Oryctolagus cuniculus | ||
| 53 | AB (u) | 40S ribosomal protein S3a | polymer | 213 | 24759.1 | 1 | UniProt (G1SS70) Pfam (PF01015) | Oryctolagus cuniculus (Rabbit) | |
| 54 | BB (v) | uS5 | polymer | 221 | 24441.8 | 1 | Oryctolagus cuniculus | ||
| 55 | CB (x) | 40S ribosomal protein S4 | polymer | 262 | 29523.7 | 1 | UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (Rabbit) | |
| 56 | DB (z) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (Rabbit) | |
| 57 | EB (y) | 40S ribosomal protein S7 | polymer | 189 | 21629.3 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (Rabbit) | |
| 58 | FB (CC) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (Rabbit) | |
| 59 | GB (XX) | Ribosomal protein S9 (Predicted) | polymer | 185 | 21649.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (Rabbit) | |
| 60 | HB (EE) | Ribosomal protein S11 | polymer | 151 | 17586.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (Rabbit) | |
| 61 | IB (QQ) | ribosomal protein uS15 | polymer | 149 | 17057.1 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (Rabbit) | |
| 62 | JB (MM) | uS11 | polymer | 136 | 14544.7 | 1 | Oryctolagus cuniculus | ||
| 63 | KB (UU) | Ribosomal protein S16 | polymer | 142 | 16032.8 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (Rabbit) | |
| 64 | LB (YY) | eS17 | polymer | 132 | 15250.7 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (Rabbit) | |
| 65 | MB (HH) | eS21 | polymer | 83 | 9124.4 | 1 | Oryctolagus cuniculus | ||
| 66 | NB (TT) | Ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (Rabbit) | |
| 67 | OB (VV) | Ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (Rabbit) | |
| 68 | PB (NN) | eS24 | polymer | 124 | 14432.1 | 1 | Oryctolagus cuniculus | ||
| 69 | QB (ZZ) | eS26 | polymer | 101 | 11645.8 | 1 | Oryctolagus cuniculus | ||
| 70 | RB (JJ) | 40S ribosomal protein S27 | polymer | 83 | 9349.0 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (Rabbit) | |
| 71 | SB (AA) | 40S ribosomal protein S30 | polymer | 55 | 6317.5 | 1 | UniProt (G1T8A2) Pfam (PF04758) | Oryctolagus cuniculus (Rabbit) | |
| 72 | TB (DD) | Ribosomal protein S3 | polymer | 228 | 25215.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (Rabbit) | |
| 73 | UB (BB) | Ribosomal protein S5 | polymer | 191 | 21525.9 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (Rabbit) | |
| 74 | VB (SS) | eS10 | polymer | 96 | 11529.7 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (Rabbit) | |
| 75 | WB (RR) | 40S ribosomal protein S12 | polymer | 117 | 13048.2 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 76 | XB (9) | uS14 | polymer | 120 | 14246.9 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (Rabbit) | |
| 77 | YB (II) | uS13 | polymer | 144 | 16898.6 | 1 | UniProt (G1SZI5) Pfam (PF00416) UniProt (by SIFTS) (G1TPG3) | Oryctolagus cuniculus (Rabbit) | |
| 78 | ZB (PP) | eS19 | polymer | 141 | 15611.0 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (Rabbit) | |
| 79 | AC (GG) | uS10 | polymer | 100 | 11395.5 | 1 | Oryctolagus cuniculus | ||
| 80 | BC (OO) | ribosomal protein eS25 | polymer | 75 | 8526.1 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (Rabbit) | |
| 81 | CC (FF) | Ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (Rabbit) | |
| 82 | DC (w) | S29 | polymer | 55 | 6559.6 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (Rabbit) | |
| 83 | EC (0) | eS31 | polymer | 68 | 7986.4 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (Rabbit) | |
| 84 | FC (6) | ribosomal protein RACK1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (Rabbit) | |
| 85 | GC (4) | mRNA | polymer | 10 | 3145.9 | 1 | Homo sapiens | ||
| 86 | AD, AE, AF, AG, AH... (5, 7, 8, I, P...) | MAGNESIUM ION | non-polymer | 24.3 | 159 | Chemie (MG) | |||
| 87 | JI, LI, MI, NI, OI (g, j, m, o, p) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
F: 26 - 250 (UniProt: G1SV32)
G: 26 - 266 (UniProt: G1STW0)
L: 2 - 211 (UniProt: G1TPV0)
Q: 2 - 188 (UniProt: G1TX70)
U: 17 - 115 (UniProt: G1TSG1)
1: 237 - 260 (UniProt: P17861)
x: 2 - 263 (UniProt: G1TK17)
CC: 2 - 207 (UniProt: G1TJW1)
PP: 3 - 143 (UniProt: G1TN62)
| PDB | External Database | Details |
|---|---|---|
| Ala 175 | Thr 174 | conflict |
| Gly 185 | Asn 184 | conflict |
| Arg 202 | His 201 | conflict |
| Glu 233 | Gly 232 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | Cys 167 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 47 | - | insertion |
| Pro 48 | - | insertion |
| Arg 49 | - | insertion |
| Pro 50 | - | insertion |
| Ala 51 | - | insertion |
| Ser 52 | - | insertion |
| Gly 53 | - | insertion |
| Pro 54 | - | insertion |
| Leu 55 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Arg 6 | Leu 6 | conflict |
| Arg 14 | Trp 14 | conflict |
| Ile 23 | Met 23 | conflict |
| Tyr 24 | Cys 24 | conflict |
| Arg 38 | His 38 | conflict |
| Asn 57 | Lys 57 | conflict |
| Met 66 | Val 66 | conflict |
| Gly 74 | Asp 74 | conflict |
| Arg 75 | Pro 75 | conflict |
| Gly 77 | Asn 77 | conflict |
| Ser 106 | Thr 106 | conflict |
| Arg 110 | His 110 | conflict |
| Gly 117 | Glu 117 | conflict |
| Asp 124 | His 124 | conflict |
| Cys 134 | Arg 134 | conflict |
| Arg 150 | Gln 150 | conflict |
| Arg 172 | Gly 172 | conflict |
| Arg 184 | Trp 184 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | Arg 32 | conflict |
| Ala 36 | Glu 36 | conflict |
| Phe 39 | Ser 39 | conflict |
| Gly 54 | Arg 54 | conflict |
| Val 60 | Ala 60 | conflict |
| Arg 97 | His 97 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 255 | Ser 255 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| Arg 51 | Lys 51 | conflict |
| Thr 78 | Ala 78 | conflict |
| Val 156 | Met 156 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | Trp 119 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 85 |
| Total formula weight | 3218015.4 | |
| Non-Polymers* | Number of molecules | 164 |
| Total formula weight | 4191.5 | |
| All* | Total formula weight | 3222206.9 |
