6R6H
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | COP9 signalosome complex subunit 1 | polymer | 491 | 55606.5 | 1 | UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151) | Homo sapiens (Human) | Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH |
| 2 | B (B) | COP9 signalosome complex subunit 2 | polymer | 443 | 51664.6 | 1 | UniProt (P61201) Pfam (PF01399) | Homo sapiens (Human) | Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15 |
| 3 | C (C) | COP9 signalosome complex subunit 3 | polymer | 403 | 45808.8 | 1 | UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215) | Homo sapiens (Human) | Signalosome subunit 3,JAB1-containing signalosome subunit 3 |
| 4 | D (D) | COP9 signalosome complex subunit 4 | polymer | 406 | 46322.7 | 1 | UniProt (Q9BT78) Pfam (PF18420) Pfam (PF22241) Pfam (PF01399) | Homo sapiens (Human) | Signalosome subunit 4,JAB1-containing signalosome subunit 4 |
| 5 | E (E) | COP9 signalosome complex subunit 5 | polymer | 334 | 37621.7 | 1 | UniProt (Q92905) Pfam (PF01398) Pfam (PF18323) | Homo sapiens (Human) | Signalosome subunit 5,Jun activation domain-binding protein 1 |
| 6 | F (F) | COP9 signalosome complex subunit 6 | polymer | 308 | 34713.8 | 1 | UniProt (Q7L5N1) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (Human) | Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP |
| 7 | G (H) | COP9 signalosome complex subunit 8 | polymer | 209 | 23245.5 | 1 | UniProt (Q99627) Pfam (PF10075) | Homo sapiens (Human) | Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8 |
| 8 | H (O) | Cullin-2 | polymer | 745 | 87098.9 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (Human) | CUL-2 |
| 9 | I (P) | Elongin-B | polymer | 105 | 11819.5 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 10 | J (Q) | ELOC_HUMAN | polymer | 99 | 11338.8 | 1 | Pfam (PF03931) UniProt (by SIFTS) (Q03071) | Homo sapiens (Human) | |
| 11 | K (R) | RBX1_HUMAN | polymer | 86 | 10092.6 | 1 | Pfam (PF12678) UniProt (by SIFTS) (P62877) | Homo sapiens (Human) | |
| 12 | L (V) | von Hippel-Lindau disease tumor suppressor | polymer | 150 | 17330.8 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 13 | M (G) | COP9 signalosome complex subunit 7b | polymer | 206 | 23228.5 | 1 | UniProt (Q9H9Q2) Pfam (PF22061) Pfam (PF01399) Pfam (PF18392) | Homo sapiens (Human) | Signalosome subunit 7b,JAB1-containing signalosome subunit 7b |
| 14 | N (E) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
C: 1 - 383 (UniProt: Q9UNS2)
P: 1 - 104 (UniProt: Q15370)
V: 60 - 207 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Ile 384 | - | expression tag |
| Glu 385 | - | expression tag |
| Leu 386 | - | expression tag |
| Asp 387 | - | expression tag |
| Glu 388 | - | expression tag |
| Arg 389 | - | expression tag |
| Leu 390 | - | expression tag |
| Lys 391 | - | expression tag |
| Ala 392 | - | expression tag |
| Met 393 | - | expression tag |
| Asp 394 | - | expression tag |
| Gln 395 | - | expression tag |
| Glu 396 | - | expression tag |
| Ile 397 | - | expression tag |
| Thr 398 | - | expression tag |
| Val 399 | - | expression tag |
| Asn 400 | - | expression tag |
| Pro 401 | - | expression tag |
| Gln 402 | - | expression tag |
| Phe 403 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 105 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 208 | - | expression tag |
| Ala 209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 455892.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 455958.2 |
