6R5F

Crystal structure of RIP1 kinase in complex with DHP77

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Receptor-interacting serine/threonine-protein kinase 1	polymer	303	34596.9	4	UniProt (Q13546) Pfam (PF07714) In PDB	Homo sapiens (Human)	Cell death protein RIP,Receptor-interacting protein 1,RIP-1,Serine/threonine-protein kinase RIP
2	A, B, C, D	[(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone	non-polymer		377.4	4	Chemie (JSW)

Sequence modifications

A, B, C, D: 1 - 294 (UniProt: Q13546)

PDB	External Database	Details
Met -8	-	initiating methionine
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Ala 34	Cys 34	engineered mutation
Ala 127	Cys 127	engineered mutation
Ala 233	Cys 233	engineered mutation
Ala 240	Cys 240	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138387.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1509.6
All*	Total formula weight	139897.1

*Water molecules are not included.