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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6R3Q

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Adenylate cyclase 9polymer1637182404.41UniProt (E1BM79)
Pfam (PF00211)		Bos taurus (cattle)Adenylyl CYclase family member (Acy-1)-like
2B
(B)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer40446932.71UniProt (P04896)
Pfam (PF00503)		Bos taurus (cattle)Adenylate cyclase-stimulating G alpha protein
3C
(B)		5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATEnon-polymer539.21Chemie (GSP)
4D
(B)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence modifications
A: 1 - 1354 (UniProt: E1BM79)
PDBExternal DatabaseDetails
Ala 1355-expression tag
Ala 1356-expression tag
Ala 1357-expression tag
Leu 1358-expression tag
Glu 1359-expression tag
Val 1360-expression tag
Leu 1361-expression tag
Phe 1362-expression tag
Gln 1363-expression tag
Gly 1364-expression tag
Pro 1365-expression tag
Gly 1366-expression tag
Gly 1367-expression tag
Val 1368-expression tag
Ser 1369-expression tag
Lys 1370-expression tag
Gly 1371-expression tag
Glu 1372-expression tag
Glu 1373-expression tag
Leu 1374-expression tag
Phe 1375-expression tag
Thr 1376-expression tag
Gly 1377-expression tag
Val 1378-expression tag
Val 1379-expression tag
Pro 1380-expression tag
Ile 1381-expression tag
Leu 1382-expression tag
Val 1383-expression tag
Glu 1384-expression tag
Leu 1385-expression tag
Asp 1386-expression tag
Gly 1387-expression tag
Asp 1388-expression tag
Val 1389-expression tag
Asn 1390-expression tag
Gly 1391-expression tag
His 1392-expression tag
Lys 1393-expression tag
Phe 1394-expression tag
Ser 1395-expression tag
Val 1396-expression tag
Ser 1397-expression tag
Gly 1398-expression tag
Glu 1399-expression tag
Gly 1400-expression tag
Glu 1401-expression tag
Gly 1402-expression tag
Asp 1403-expression tag
Ala 1404-expression tag
Thr 1405-expression tag
Tyr 1406-expression tag
Gly 1407-expression tag
Lys 1408-expression tag
Leu 1409-expression tag
Thr 1410-expression tag
Leu 1411-expression tag
Lys 1412-expression tag
Phe 1413-expression tag
Ile 1414-expression tag
Cys 1415-expression tag
Thr 1416-expression tag
Thr 1417-expression tag
Gly 1418-expression tag
Lys 1419-expression tag
Leu 1420-expression tag
Pro 1421-expression tag
Val 1422-expression tag
Pro 1423-expression tag
Trp 1424-expression tag
Pro 1425-expression tag
Thr 1426-expression tag
Leu 1427-expression tag
Val 1428-expression tag
Thr 1429-expression tag
Thr 1430-expression tag
Phe 1431-expression tag
Gly 1432-expression tag
Tyr 1433-expression tag
Gly 1434-expression tag
Leu 1435-expression tag
Gln 1436-expression tag
Cys 1437-expression tag
Phe 1438-expression tag
Ala 1439-expression tag
Arg 1440-expression tag
Tyr 1441-expression tag
Pro 1442-expression tag
Asp 1443-expression tag
His 1444-expression tag
Met 1445-expression tag
Lys 1446-expression tag
Gln 1447-expression tag
His 1448-expression tag
Asp 1449-expression tag
Phe 1450-expression tag
Phe 1451-expression tag
Lys 1452-expression tag
Ser 1453-expression tag
Ala 1454-expression tag
Met 1455-expression tag
Pro 1456-expression tag
Glu 1457-expression tag
Gly 1458-expression tag
Tyr 1459-expression tag
Val 1460-expression tag
Gln 1461-expression tag
Glu 1462-expression tag
Arg 1463-expression tag
Thr 1464-expression tag
Ile 1465-expression tag
Phe 1466-expression tag
Phe 1467-expression tag
Lys 1468-expression tag
Asp 1469-expression tag
Asp 1470-expression tag
Gly 1471-expression tag
Asn 1472-expression tag
Tyr 1473-expression tag
Lys 1474-expression tag
Thr 1475-expression tag
Arg 1476-expression tag
Ala 1477-expression tag
Glu 1478-expression tag
Val 1479-expression tag
Lys 1480-expression tag
Phe 1481-expression tag
Glu 1482-expression tag
Gly 1483-expression tag
Asp 1484-expression tag
Thr 1485-expression tag
Leu 1486-expression tag
Val 1487-expression tag
Asn 1488-expression tag
Arg 1489-expression tag
Ile 1490-expression tag
Glu 1491-expression tag
Leu 1492-expression tag
Lys 1493-expression tag
Gly 1494-expression tag
Ile 1495-expression tag
Asp 1496-expression tag
Phe 1497-expression tag
Lys 1498-expression tag
Glu 1499-expression tag
Asp 1500-expression tag
Gly 1501-expression tag
Asn 1502-expression tag
Ile 1503-expression tag
Leu 1504-expression tag
Gly 1505-expression tag
His 1506-expression tag
Lys 1507-expression tag
Leu 1508-expression tag
Glu 1509-expression tag
Tyr 1510-expression tag
Asn 1511-expression tag
Tyr 1512-expression tag
Asn 1513-expression tag
Ser 1514-expression tag
His 1515-expression tag
Asn 1516-expression tag
Val 1517-expression tag
Tyr 1518-expression tag
Ile 1519-expression tag
Met 1520-expression tag
Ala 1521-expression tag
Asp 1522-expression tag
Lys 1523-expression tag
Gln 1524-expression tag
Lys 1525-expression tag
Asn 1526-expression tag
Gly 1527-expression tag
Ile 1528-expression tag
Lys 1529-expression tag
Val 1530-expression tag
Asn 1531-expression tag
Phe 1532-expression tag
Lys 1533-expression tag
Ile 1534-expression tag
Arg 1535-expression tag
His 1536-expression tag
Asn 1537-expression tag
Ile 1538-expression tag
Glu 1539-expression tag
Asp 1540-expression tag
Gly 1541-expression tag
Ser 1542-expression tag
Val 1543-expression tag
Gln 1544-expression tag
Leu 1545-expression tag
Ala 1546-expression tag
Asp 1547-expression tag
His 1548-expression tag
Tyr 1549-expression tag
Gln 1550-expression tag
Gln 1551-expression tag
Asn 1552-expression tag
Thr 1553-expression tag
Pro 1554-expression tag
Ile 1555-expression tag
Gly 1556-expression tag
Asp 1557-expression tag
Gly 1558-expression tag
Pro 1559-expression tag
Val 1560-expression tag
Leu 1561-expression tag
Leu 1562-expression tag
Pro 1563-expression tag
Asp 1564-expression tag
Asn 1565-expression tag
His 1566-expression tag
Tyr 1567-expression tag
Leu 1568-expression tag
Ser 1569-expression tag
Tyr 1570-expression tag
Gln 1571-expression tag
Ser 1572-expression tag
Ala 1573-expression tag
Leu 1574-expression tag
Ser 1575-expression tag
Lys 1576-expression tag
Asp 1577-expression tag
Pro 1578-expression tag
Asn 1579-expression tag
Glu 1580-expression tag
Lys 1581-expression tag
Arg 1582-expression tag
Asp 1583-expression tag
His 1584-expression tag
Met 1585-expression tag
Val 1586-expression tag
Leu 1587-expression tag
Leu 1588-expression tag
Glu 1589-expression tag
Phe 1590-expression tag
Val 1591-expression tag
Thr 1592-expression tag
Ala 1593-expression tag
Ala 1594-expression tag
Gly 1595-expression tag
Ile 1596-expression tag
Thr 1597-expression tag
Leu 1598-expression tag
Gly 1599-expression tag
Met 1600-expression tag
Asp 1601-expression tag
Glu 1602-expression tag
Leu 1603-expression tag
Tyr 1604-expression tag
Lys 1605-expression tag
Ala 1606-expression tag
Ala 1607-expression tag
Ser 1608-expression tag
Ala 1609-expression tag
Trp 1610-expression tag
Ser 1611-expression tag
His 1612-expression tag
Pro 1613-expression tag
Gln 1614-expression tag
Phe 1615-expression tag
Glu 1616-expression tag
Lys 1617-expression tag
Gly 1618-expression tag
Gly 1619-expression tag
Gly 1620-expression tag
Ser 1621-expression tag
Gly 1622-expression tag
Gly 1623-expression tag
Gly 1624-expression tag
Ser 1625-expression tag
Gly 1626-expression tag
Gly 1627-expression tag
Ser 1628-expression tag
Ala 1629-expression tag
Trp 1630-expression tag
Ser 1631-expression tag
His 1632-expression tag
Pro 1633-expression tag
Gln 1634-expression tag
Phe 1635-expression tag
Glu 1636-expression tag
Lys 1637-expression tag
B: 1 - 394 (UniProt: P04896)
PDBExternal DatabaseDetails
Gly 71-insertion
Asn 79Gln 78conflict
-Ala 80deletion
Lys 81Arg 81conflict
Gly 395-expression tag
Gly 396-expression tag
His 397-expression tag
His 398-expression tag
His 399-expression tag
His 400-expression tag
His 401-expression tag
His 402-expression tag
His 403-expression tag
His 404-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight229337.1
Non-Polymers*Number of molecules2
Total formula weight563.6
All*Total formula weight229900.7
*Water molecules are not included.

246333

PDB entries from 2025-12-17

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