6R15

Crystal structure of the SUN1-KASH1 6:6 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SUN domain-containing protein 1	polymer	203	22530.4	1	UniProt (O94901) Pfam (PF07738) In PDB	Homo sapiens (Human)	Protein unc-84 homolog A,Sad1/unc-84 protein-like 1
2	B	Nesprin-1	polymer	32	3606.0	1	UniProt (Q8NF91) Pfam (PF10541) In PDB	Homo sapiens (Human)	Enaptin,KASH domain-containing protein 1,KASH1,Myocyte nuclear envelope protein 1,Myne-1,Nuclear envelope spectrin repeat protein 1,Synaptic nuclear envelope protein 1,Syne-1
3	A	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
4	A	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
5	A	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
6		water	water		18.0	236	Chemie (HOH)

Sequence modifications

A: 616 - 812 (UniProt: O94901)

PDB	External Database	Details
Gly 610	-	expression tag
Ser 611	-	expression tag
Gly 612	-	expression tag
Gly 613	-	expression tag
Ser 614	-	expression tag
Gly 615	-	expression tag

B: 8769 - 8797 (UniProt: Q8NF91)

PDB	External Database	Details
Gly 8766	-	expression tag
Ser 8767	-	expression tag
Met 8768	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26136.4
Non-Polymers*	Number of molecules	3
	Total formula weight	427.6
All*	Total formula weight	26564.0

*Water molecules are not included.