6QXH
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Thymidylate synthase | polymer | 325 | 37214.5 | 3 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens | TSase |
2 | A, B, C | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 3 | Chemie (UMP) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | C | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 111643.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1162.2 | |
All* | Total formula weight | 112805.8 |