6QXH

Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Thymidylate synthase	polymer	325	37214.5	3	UniProt (P04818) Pfam (PF00303)	Homo sapiens	TSase
2	D, G, H (A, B, C)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	3	Chemie (UMP)
3	E (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
4	F (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	I (C)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	J, K, L (A, B, C)	water	water		18.0	205	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 313 (UniProt: P04818)

PDB	External Database	Details
Met -11	-	initiating methionine
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	111643.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1162.2
All*	Total formula weight	112805.8

*Water molecules are not included.