6QXG

Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Thymidylate synthase	polymer	325	37168.5	3	UniProt (P04818) Pfam (PF00303) In PDB	Homo sapiens (Human)	TSase
2	A, B, C	5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE	non-polymer		326.2	3	Chemie (UFP)
3	C	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4		water	water		18.0	413	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 313 (UniProt: P04818)

PDB	External Database	Details
Met -11	-	initiating methionine
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	111505.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1074.6
All*	Total formula weight	112579.9

*Water molecules are not included.