6QXG
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Thymidylate synthase | polymer | 325 | 37168.5 | 3 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (Human) | TSase |
| 2 | D, E, F (A, B, C) | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 326.2 | 3 | Chemie (UFP) | |||
| 3 | G (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | H, I, J (A, B, C) | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | initiating methionine |
| Arg -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111505.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1074.6 | |
| All* | Total formula weight | 112579.9 |
