6QTJ
Crystal structure of human CDK8/CYCC in complex with BI 919811
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 8 | polymer | 405 | 46890.7 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B | Cyclin-C | polymer | 285 | 33423.8 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | A | ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide | non-polymer | 357.4 | 1 | Chemie (JHK) | |||
| 4 | water | water | 18.0 | 253 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80314.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 357.4 | |
| All* | Total formula weight | 80671.9 |
