Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

6QMD

Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Kelch-like ECH-associated protein 1polymer32135251.41UniProt (Q9Z2X8)
Pfam (PF01344)
Mus musculus (House mouse)Cytosolic inhibitor of Nrf2,INrf2
2B
(A)
DIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
3C, D
(A)
(3~{R})-3-(4-chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acidnon-polymer315.82Chemie (J6N)
4E
(A)
waterwater18.0353Chemie (HOH)
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
PDBExternal DatabaseDetails
Met 304-initiating methionine
Gly 305-expression tag
Ser 306-expression tag
Ser 307-expression tag
His 308-expression tag
His 309-expression tag
His 310-expression tag
His 311-expression tag
His 312-expression tag
His 313-expression tag
Ser 314-expression tag
Ser 315-expression tag
Gly 316-expression tag
Leu 317-expression tag
Val 318-expression tag
Pro 319-expression tag
Arg 320-expression tag
Gly 321-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight35251.4
Non-Polymers*Number of molecules3
Total formula weight709.6
All*Total formula weight35961.0
*Water molecules are not included.

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon