6QMC
Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Kelch-like ECH-associated protein 1 | polymer | 321 | 35251.4 | 1 | UniProt (Q9Z2X8) Pfam (PF01344) In PDB | Mus musculus (Mouse) | Cytosolic inhibitor of Nrf2,INrf2 |
2 | A | (3~{S})-3-(4-chlorophenyl)-3-(2-oxidanylidene-1~{H}-pyridin-4-yl)propanoic acid | non-polymer | 277.7 | 1 | Chemie (J6H) | |||
3 | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A: 322 - 624 (UniProt: Q9Z2X8)
PDB | External Database | Details |
---|---|---|
Met 304 | - | initiating methionine |
Gly 305 | - | expression tag |
Ser 306 | - | expression tag |
Ser 307 | - | expression tag |
His 308 | - | expression tag |
His 309 | - | expression tag |
His 310 | - | expression tag |
His 311 | - | expression tag |
His 312 | - | expression tag |
His 313 | - | expression tag |
Ser 314 | - | expression tag |
Ser 315 | - | expression tag |
Gly 316 | - | expression tag |
Leu 317 | - | expression tag |
Val 318 | - | expression tag |
Pro 319 | - | expression tag |
Arg 320 | - | expression tag |
Gly 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35251.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 277.7 | |
All* | Total formula weight | 35529.1 |