6QLE

Structure of inner kinetochore CCAN complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Central kinetochore subunit MCM16,Central kinetochore subunit MCM16,Inner kinetochore subunit MCM16,Mcm16p	polymer	181	20019.2	1	UniProt (B3LLA4) Pfam (PF20993) UniProt (by SIFTS) (Q12262)	Saccharomyces cerevisiae (Baker's yeast)
2	B (I)	Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3,Central kinetochore subunit CTF3,Inner kinetochore subunit CTF3	polymer	412	46149.9	1	UniProt (Q12748)	Saccharomyces cerevisiae (Baker's yeast)
3	C (K)	Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22,Inner kinetochore subunit MCM22	polymer	204	21431.9	1	UniProt (P47167)	Saccharomyces cerevisiae (Baker's yeast)	CENP-K homolog,Constitutive centromere-associated network protein MCM22,Minichromosome maintenance protein 22
4	D (L)	Inner kinetochore subunit IML3	polymer	245	28093.2	1	UniProt (P38265)	Saccharomyces cerevisiae (Baker's yeast)	CENP-L homolog,Constitutive centromere-associated network protein IML3,Increased minichromosome loss protein 3,Minichromosome maintenance protein 19
5	E (N)	Inner kinetochore subunit CHL4	polymer	458	52743.7	1	UniProt (P38907) Pfam (PF05238)	Saccharomyces cerevisiae (Baker's yeast)	CENP-N homolog,Chromosome loss protein 4,Chromosome transmission fidelity protein 17,Constitutive centromere-associated network protein CHL4,Minichromosome maintenance protein 17
6	F (O)	Inner kinetochore subunit MCM21	polymer	368	43028.9	1	UniProt (Q06675) Pfam (PF09496)	Saccharomyces cerevisiae (Baker's yeast)	CENP-O homolog,Chromosome transmission fidelity protein 5,Constitutive centromere-associated network protein MCM21,Minichromosome maintenance protein 21
7	G (P)	Inner kinetochore subunit CTF19	polymer	369	42841.1	1	UniProt (Q02732)	Saccharomyces cerevisiae (Baker's yeast)	CENP-P homolog,Chromosome transmission fidelity protein 19,Constitutive centromere-associated network protein CTF19,Minichromosome maintenance protein 18
8	H (Q)	Inner kinetochore subunit OKP1,Inner kinetochore subunit OKP1,Inner kinetochore subunit OKP1,Inner kinetochore subunit OKP1	polymer	261	30460.8	1	UniProt (P53298)	Saccharomyces cerevisiae (Baker's yeast)	CENP-Q homolog,Constitutive centromere-associated network protein OKP1,Outer kinetochore protein 1
9	I (U)	Inner kinetochore subunit AME1,Inner kinetochore subunit AME1,Inner kinetochore subunit AME1,Inner kinetochore subunit AME1	polymer	186	20941.0	1	UniProt (P38313) Pfam (PF20994)	Saccharomyces cerevisiae (Baker's yeast)	Associated with microtubules and essential protein 1,CENP-U homolog,Constitutive centromere-associated network protein AME1
10	J (Y)	Inner kinetochore subunit NKP1	polymer	238	27006.5	1	UniProt (Q12493)	Saccharomyces cerevisiae (Baker's yeast)	Constitutive centromere-associated network protein NKP1,Non-essential kinetochore protein 1
11	K (Z)	Inner kinetochore subunit NKP2	polymer	153	17877.0	1	UniProt (Q06162) Pfam (PF09447)	Saccharomyces cerevisiae (Baker's yeast)	Constitutive centromere-associated network protein NKP2,Non-essential kinetochore protein 2

Sequence modifications

H: 1 - 136 (UniProt: B3LLA4)
H: 137 - 181 (PDB: 6QLE)
I: 321 - 334 (PDB: 6QLE)
I: 335 - 656 (UniProt: Q12748)
I: 656 - 676 (PDB: 6QLE)
I: 690 - 733 (UniProt: Q12748)
K: 1 - 133 (UniProt: P47167)
K: 134 - 204 (PDB: 6QLE)
Q: 125 - 139 (PDB: 6QLE)
Q: 160 - 406 (UniProt: P53298)
U: 130 - 156 (PDB: 6QLE)
U: 166 - 324 (UniProt: P38313)

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	350593.3
All*	Total formula weight	350593.3

*Water molecules are not included.