6QHC
Crystal Structure of Human Kallikrein 6 in complex with GSK358180B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Kallikrein-6 | polymer | 223 | 24417.7 | 2 | UniProt (Q92876) Pfam (PF00089) In PDB | Homo sapiens (Human) | Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | A, B | N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE | non-polymer | 255.3 | 2 | Chemie (135) | |||
| 4 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: Q92876)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | Arg 78 | engineered mutation |
| Gln 76 | Arg 80 | engineered mutation |
| Gln 132 | Asn 134 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48835.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 680.8 | |
| All* | Total formula weight | 49516.2 |
