6QH4

Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, A, B, D)	Methylmalonyl-CoA epimerase, mitochondrial	polymer	155	16799.5	4	UniProt (Q96PE7) Pfam (PF13669)	Homo sapiens (Human)	DL-methylmalonyl-CoA racemase
2	E, F, G, H (C, A, B, D)	COBALT (II) ION	non-polymer		58.9	4	Chemie (CO)
3	I, J, K, L (C, A, B, D)	water	water		18.0	90	Chemie (HOH)

Sequence modifications

C, A, B, D: 45 - 176 (UniProt: Q96PE7)

PDB	External Database	Details
Met 22	-	initiating methionine
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
Ser 29	-	expression tag
Ser 30	-	expression tag
Gly 31	-	expression tag
Val 32	-	expression tag
Asp 33	-	expression tag
Leu 34	-	expression tag
Gly 35	-	expression tag
Thr 36	-	expression tag
Glu 37	-	expression tag
Asn 38	-	expression tag
Leu 39	-	expression tag
Tyr 40	-	expression tag
Phe 41	-	expression tag
Gln 42	-	expression tag
Ser 43	-	expression tag
Met 44	-	expression tag
Leu 104	Arg 104	variant
Cys 143	Arg 143	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	67198.0
Non-Polymers*	Number of molecules	4
	Total formula weight	235.7
All*	Total formula weight	67433.7

*Water molecules are not included.