6QGJ
Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | polymer | 177 | 20442.5 | 1 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X,Bcl2-L-1,Apoptosis regulator Bcl-X |
2 | A | 4-[4-[(1~{R})-1-(6-methoxy-1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-ethyl]phenyl]-~{N}-[4-[[(2~{R})-4-morpholin-4-yl-1-phenylsulfanyl-butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonyl-benzamide | non-polymer | 981.1 | 1 | Chemie (J1T) | |||
3 | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 10 - 33 (UniProt: P10415)
A: 34 - 49 (UniProt: Q07817)
A: 92 - 203 (UniProt: P10415)
A: 204 - 217 (UniProt: Q07817)
PDB | External Database | Details |
---|---|---|
Met 7 | - | initiating methionine |
Ser 8 | - | expression tag |
Gln 9 | - | expression tag |
Ser 20 | His 20 | engineered mutation |
A: 92 - 203 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Gln 95 | Leu 95 | engineered mutation |
Leu 106 | Arg 106 | engineered mutation |
Gly 124 | Phe 124 | engineered mutation |
Tyr 127 | Arg 127 | engineered mutation |
Ala 128 | Gly 128 | engineered mutation |
Ser 129 | Arg 129 | engineered mutation |
Val 168 | Pro 168 | engineered mutation |
Ala 175 | Leu 175 | engineered mutation |
Ala 178 | Thr 178 | engineered mutation |
Thr 179 | Glu 179 | engineered mutation |
Asp 183 | Arg 183 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Leu 218 | - | expression tag |
Glu 219 | - | expression tag |
His 220 | - | expression tag |
His 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
His 225 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 20442.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 981.1 | |
All* | Total formula weight | 21423.6 |