6QCH
Human Sirt6 in complex with ADP-ribose and the activator cyanidin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-6 | polymer | 302 | 33631.6 | 2 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 6,SIR2-like protein 6 |
| 2 | C, M (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 3 | D, N (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, G, O (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 5 | H, I, J, K, P... (A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 6 | L, V (A, B) | cyanidin | non-polymer | 287.2 | 2 | Chemie (HWB) | |||
| 7 | W, X (A, B) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B: 13 - 308 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Ile 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Thr 12 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67263.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3032.8 | |
| All* | Total formula weight | 70296.0 |
