6Q9Z

Crystal structure of the pathological G167R variant of calcium-free human gelsolin,

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Gelsolin	polymer	778	85617.8	2	UniProt (P06396) Pfam (PF00626) In PDB	Homo sapiens (Human)	AGEL,Actin-depolymerizing factor,ADF,Brevin
2	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4		water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, B: 1 - 755 (UniProt: P06396)

PDB	External Database	Details
Met -22	-	initiating methionine
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Arg 167	Gly 194	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	171235.7
Non-Polymers*	Number of molecules	4
	Total formula weight	376.3
All*	Total formula weight	171612.0

*Water molecules are not included.