6Q2P
Crystal structure of mouse viperin bound to cytidine triphosphate and S-adenosylhomocysteine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Radical S-adenosyl methionine domain-containing protein 2 | polymer | 318 | 36694.7 | 2 | UniProt (Q8CBB9) Pfam (PF13353) Pfam (PF04055) | Mus musculus (Mouse) | Viperin,Virus inhibitory protein,endoplasmic reticulum-associated,interferon-inducible |
| 2 | C, I (A, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 3 | D, J (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | E, K (A, B) | CYTIDINE-5'-TRIPHOSPHATE | non-polymer | 483.2 | 2 | Chemie (CTP) | |||
| 5 | F, G, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | H (B) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 362 (UniProt: Q8CBB9)
| PDB | External Database | Details |
|---|---|---|
| Leu 55 | Pro 55 | conflict |
| Glu 57 | Asp 57 | conflict |
| Arg 70 | Pro 70 | conflict |
| Ala 261 | Glu 261 | engineered mutation |
| Ala 266 | Glu 266 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73389.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2827.1 | |
| All* | Total formula weight | 76216.5 |
