6Q2P
Crystal structure of mouse viperin bound to cytidine triphosphate and S-adenosylhomocysteine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Radical S-adenosyl methionine domain-containing protein 2 | polymer | 318 | 36694.7 | 2 | UniProt (Q8CBB9) Pfam (PF13353) Pfam (PF04055) | Mus musculus (Mouse) | Viperin,Virus inhibitory protein,endoplasmic reticulum-associated,interferon-inducible |
| 2 | C, I (A, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 3 | D, J (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | E, K (A, B) | CYTIDINE-5'-TRIPHOSPHATE | non-polymer | 483.2 | 2 | Chemie (CTP) | |||
| 5 | F, G, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 6 | H (B) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) PubChem (125132) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 362 (UniProt: Q8CBB9)
| PDB | External Database | Details |
|---|---|---|
| Leu 55 | Pro 55 | conflict |
| Glu 57 | Asp 57 | conflict |
| Arg 70 | Pro 70 | conflict |
| Ala 261 | Glu 261 | engineered mutation |
| Ala 266 | Glu 266 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73389.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2827.1 | |
| All* | Total formula weight | 76216.5 |
