6Q06
MERS-CoV S structure in complex with 2,3-sialyl-N-acetyl-lactosamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1359 | 149172.1 | 3 | UniProt (K0BRG7) | Human betacoronavirus 2c EMC/2012 | S glycoprotein,E2,Peplomer protein |
| 2 | D, DA, H, O, S... (D, d, H, O, S...) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 6 | In PDB GlyTouCan (G81315DD) | |||
| 3 | AA, E, EA, FA, I... (a, E, e, f, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 4 | BA, F, Q (b, F, Q) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G89619KY) | |||
| 5 | CA, G, R (c, G, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | GA, HA, K, L, V... (g, h, K, L, V...) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) | |||
| 7 | JA, N, Y (j, N, Y) | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | branched | 471.4 | 3 | In PDB GlyTouCan (G30207PZ) | |||
| 8 | AB, BB, CB, DB, EB... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) | |||
| 9 | HB, RA, ZA (C, A, B) | FOLIC ACID | non-polymer | 441.4 | 3 | Chemie (FOL) | |||
| 10 | IB, JB, KB (A, B, C) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B, C: 19 - 1294 (UniProt: K0BRG7)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ile -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Met -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Val 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Val 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Met 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Cys 12 | - | expression tag |
| Val 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Thr 16 | - | expression tag |
| Gly 17 | - | expression tag |
| Thr 18 | - | expression tag |
| Ala 748 | Arg 748 | engineered mutation |
| Gly 751 | Arg 751 | engineered mutation |
| Pro 1060 | Val 1060 | engineered mutation |
| Pro 1061 | Leu 1061 | engineered mutation |
| Gly 1295 | - | expression tag |
| Ser 1296 | - | expression tag |
| Gly 1297 | - | expression tag |
| Arg 1298 | - | expression tag |
| Glu 1299 | - | expression tag |
| Asn 1300 | - | expression tag |
| Leu 1301 | - | expression tag |
| Tyr 1302 | - | expression tag |
| Phe 1303 | - | expression tag |
| Gln 1304 | - | expression tag |
| Gly 1305 | - | expression tag |
| Gly 1306 | - | expression tag |
| Gly 1307 | - | expression tag |
| Gly 1308 | - | expression tag |
| Ser 1309 | - | expression tag |
| Gly 1310 | - | expression tag |
| Tyr 1311 | - | expression tag |
| Ile 1312 | - | expression tag |
| Pro 1313 | - | expression tag |
| Glu 1314 | - | expression tag |
| Ala 1315 | - | expression tag |
| Pro 1316 | - | expression tag |
| Arg 1317 | - | expression tag |
| Asp 1318 | - | expression tag |
| Gly 1319 | - | expression tag |
| Gln 1320 | - | expression tag |
| Ala 1321 | - | expression tag |
| Tyr 1322 | - | expression tag |
| Val 1323 | - | expression tag |
| Arg 1324 | - | expression tag |
| Lys 1325 | - | expression tag |
| Asp 1326 | - | expression tag |
| Gly 1327 | - | expression tag |
| Glu 1328 | - | expression tag |
| Trp 1329 | - | expression tag |
| Val 1330 | - | expression tag |
| Leu 1331 | - | expression tag |
| Leu 1332 | - | expression tag |
| Ser 1333 | - | expression tag |
| Thr 1334 | - | expression tag |
| Phe 1335 | - | expression tag |
| Leu 1336 | - | expression tag |
| Gly 1337 | - | expression tag |
| His 1338 | - | expression tag |
| His 1339 | - | expression tag |
| His 1340 | - | expression tag |
| His 1341 | - | expression tag |
| His 1342 | - | expression tag |
| His 1343 | - | expression tag |
| His 1344 | - | expression tag |
| His 1345 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 447516.2 | |
| Branched | Number of molecules | 33 |
| Total formula weight | 21929.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5969.6 | |
| All* | Total formula weight | 475414.8 |
