6PZE
Crystal structure of human NA-45 Fab in complex with neuraminidase Y169aH mutant from A/Shanghai/2/2013 (H7N9)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neuraminidase | polymer | 393 | 44014.0 | 1 | UniProt (V9NZ28) Pfam (PF00064) UniProt (by SIFTS) (R4NFR6) | Influenza A virus (A/Shanghai/02/2013(H7N9)) | |
| 2 | B (L) | NA-45 FAB LIGHT CHAIN | polymer | 217 | 22909.3 | 1 | Homo sapiens (Human) | ||
| 3 | C (H) | NA-45 FAB HEAVY CHAIN | polymer | 237 | 25364.3 | 1 | Homo sapiens (Human) | ||
| 4 | D (B) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G91704UR) | |||
| 5 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G, H, I (A, L, H) | water | water | 18.0 | 590 | Chemie (HOH) |
Sequence modifications
A: 82 - 468 (UniProt: V9NZ28)
| PDB | External Database | Details |
|---|---|---|
| Gly 77 | - | expression tag |
| Ser 78 | - | expression tag |
| Pro 79 | - | expression tag |
| Ser 80 | - | expression tag |
| Arg 81 | - | expression tag |
| His 169 | Tyr 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 92287.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2145.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 94473.6 |
