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6PZ4

co-crystal structure of BACE with inhibitor AM-6494

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABeta-secretase 1polymer41145878.51UniProt (P56817)
Pfam (PF00026)
In PDB
Homo sapiens (Human)Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2
2AIODIDE IONnon-polymer126.93Chemie (IOD)
3AGLYCEROLnon-polymer92.12Chemie (GOL)
4AN-{3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl}-5-[(prop-2-yn-1-yl)oxy]pyrazine-2-carboxamidenon-polymer473.51Chemie (P6J)
5waterwater18.0368Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight45878.5
Non-Polymers*Number of molecules6
Total formula weight1038.4
All*Total formula weight46916.9
*Water molecules are not included.

221716

PDB entries from 2024-06-26

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