6PYR
Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1018 | 116600.6 | 1 | UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta |
| 2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 169 | 20879.6 | 1 | UniProt (P27986) Pfam (PF16454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | A | (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one | non-polymer | 446.5 | 1 | Chemie (P5J) | |||
| 4 | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
B: 431 - 599 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Asp 469 | Glu 169 | conflict |
| Thr 519 | Lys 219 | conflict |
| Glu 529 | Asp 229 | conflict |
| Val 539 | Ile 239 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 137480.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 446.5 | |
| All* | Total formula weight | 137926.7 |
