6PXU
Crystal structure of human GalNAc-T12 bound to a diglycosylated peptide, Mn2+, and UDP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Polypeptide N-acetylgalactosaminyltransferase 12 | polymer | 543 | 62739.0 | 2 | UniProt (Q8IXK2) Pfam (PF00535) Pfam (PF00652) | Homo sapiens (Human) | Polypeptide GalNAc transferase 12,pp-GaNTase 12,Protein-UDP acetylgalactosaminyltransferase 12,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 |
| 2 | C, D (C, D) | GAGATGAGAGYYITPRTGAGA | polymer | 21 | 1841.0 | 2 | synthetic construct | ||
| 3 | E, Q (A, B) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 2 | Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (3084486) PubChem (6101632) PubChem (6604175) PubChem (11811538) PubChem (12049241) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (57448939) PubChem (53486216) PubChem (60098857) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) | |||
| 4 | AA, BA, CA, F, G... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 5 | I, J, K, U, V... (A, B) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 6 | DA, N, O, P (B, A) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) PubChem (27854) | |||
| 7 | EA, FA, GA, HA (C, D) | 2-acetamido-2-deoxy-alpha-D-galactopyranose | non-polymer | 221.2 | 4 | Chemie (A2G) | |||
| 8 | IA, JA, KA, LA (A, B, C, D) | water | water | 18.0 | 562 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129159.9 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3394.5 | |
| All* | Total formula weight | 132554.4 |
