6PV7
Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562 | polymer | 525 | 60087.4 | 2 | UniProt (P32297) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 2 | B, C, E (B, C, E) | Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 | polymer | 538 | 61337.6 | 3 | UniProt (P30926) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 3 | F, H (F, H) | IgG2b Fab heavy chain | polymer | 219 | 23396.1 | 2 | Mus musculus (house mouse) | ||
| 4 | G, I (G, I) | Kappa Fab light chain | polymer | 213 | 23401.9 | 2 | Mus musculus (house mouse) | ||
| 5 | J, P (J, P) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, M, O, Q, S (K, M, O, Q, S) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 7 | L, N, R (L, N, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 8 | GA, T (D, A) | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 2 | Chemie (NCT) PubChem (942) PubChem (89594) PubChem (157672) | |||
| 9 | AA, DA, EA, HA, IA... (B, C, D, E, A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 10 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 10 | W (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 11 | BA, CA, JA, KA, X... (C, E, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 12 | FA (C) | nonane | non-polymer | 128.3 | 1 | Chemie (DD9) PubChem (8141) | |||
| 13 | NA, OA, PA, QA (B, C, D, E) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 327 (UniProt: P32297)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
A, D: 331 - 474 (UniProt: P32297)
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
B, C, E: 332 - 477 (UniProt: P30926)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
| PDB | External Database | Details |
|---|---|---|
| Trp 328 | Met 29 | conflict |
| Ile 331 | His 124 | conflict |
| Leu 331 | - | linker |
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
| PDB | External Database | Details |
|---|---|---|
| Trp 328 | Met 29 | conflict |
| Ile 332 | His 124 | conflict |
| Leu 332 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 478 | - | expression tag |
| Ala 479 | - | expression tag |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 397783.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 7162.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6670.2 | |
| All* | Total formula weight | 411616.1 |
