6PV7
Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562 | polymer | 525 | 60087.4 | 2 | UniProt (P32297) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 2 | B, C, E (B, C, E) | Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 | polymer | 538 | 61337.6 | 3 | UniProt (P30926) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 3 | F, H (F, H) | IgG2b Fab heavy chain | polymer | 219 | 23396.1 | 2 | Mus musculus (house mouse) | ||
| 4 | G, I (G, I) | Kappa Fab light chain | polymer | 213 | 23401.9 | 2 | Mus musculus (house mouse) | ||
| 5 | J, P (J, P) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, M, O, Q, S (K, M, O, Q, S) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 7 | L, N, R (L, N, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 8 | GA, T (D, A) | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 2 | Chemie (NCT) | |||
| 9 | AA, DA, EA, HA, IA... (B, C, D, E, A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 10 | Chemie (Y01) | |||
| 10 | W (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 11 | BA, CA, JA, KA, X... (C, E, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 12 | FA (C) | nonane | non-polymer | 128.3 | 1 | Chemie (DD9) | |||
| 13 | NA, OA, PA, QA (B, C, D, E) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 327 (UniProt: P32297)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
A, D: 331 - 474 (UniProt: P32297)
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
B, C, E: 332 - 477 (UniProt: P30926)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
| PDB | External Database | Details |
|---|---|---|
| Trp 328 | Met 29 | conflict |
| Ile 331 | His 124 | conflict |
| Leu 331 | - | linker |
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
| PDB | External Database | Details |
|---|---|---|
| Trp 328 | Met 29 | conflict |
| Ile 332 | His 124 | conflict |
| Leu 332 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 478 | - | expression tag |
| Ala 479 | - | expression tag |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 397783.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 7162.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6670.2 | |
| All* | Total formula weight | 411616.1 |
