6PUW
Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Chimeric Sso7d and HIV-1 integrase | polymer | 383 | 42321.3 | 4 | UniProt (P39476) UniProt (Q76353) Pfam (PF02294) UniProt (by SIFTS) (P12497) | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 7 kDa DNA-binding protein d,Sso7d |
| 2 | E (E) | viral DNA non-transferred strand | polymer | 27 | 8188.3 | 1 | Human immunodeficiency virus 1 | ||
| 3 | F (F) | viral DNA transferred strand | polymer | 25 | 7773.0 | 1 | Human immunodeficiency virus 1 | ||
| 4 | G, H (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | I, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | J (A) | Bictegravir | non-polymer | 449.4 | 1 | Chemie (KLQ) PubChem (130193042) PubChem (146433978) PubChem (90242174) PubChem (90311989) PubChem (90328411) PubChem (118596030) PubChem (118615004) PubChem (118660601) PubChem (129130827) PubChem (132152471) PubChem (137706020) PubChem (138970569) PubChem (146300638) PubChem (156758090) PubChem (173849404) PubChem (174165821) | |||
| 7 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -74 - -11 (UniProt: P39476)
A, B, C, D: 1 - 288 (UniProt: Q76353)
| PDB | External Database | Details |
|---|---|---|
| Met -94 | - | expression tag |
| Gly -93 | - | expression tag |
| Ser -92 | - | expression tag |
| Ser -91 | - | expression tag |
| His -90 | - | expression tag |
| His -89 | - | expression tag |
| His -88 | - | expression tag |
| His -87 | - | expression tag |
| His -86 | - | expression tag |
| His -85 | - | expression tag |
| Ser -84 | - | expression tag |
| Ser -83 | - | expression tag |
| Gly -82 | - | expression tag |
| Leu -81 | - | expression tag |
| Val -80 | - | expression tag |
| Pro -79 | - | expression tag |
| Arg -78 | - | expression tag |
| Gly -77 | - | expression tag |
| Ser -76 | - | expression tag |
| His -75 | - | expression tag |
| Gly -10 | - | linker |
| Gly -9 | - | linker |
| Gly -8 | - | linker |
| Gly -7 | - | linker |
| Gly -6 | - | linker |
| Gly -5 | - | linker |
| Gly -4 | - | linker |
| Gly -3 | - | linker |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Gly 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 185246.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 628.8 | |
| All* | Total formula weight | 185875.1 |
