6PR6
S. aureus dihydrofolate reductase co-crystallized with para-tolyl-dihydropthalazine inhibitor and NADP(H)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 163 | 18742.5 | 1 | UniProt (P0A017) Pfam (PF00186) In PDB | Staphylococcus aureus | DHFR |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(4-methylphenyl)phthalazin-2(1H)-yl]prop-2-en-1-one | non-polymer | 534.6 | 1 | Chemie (OWS) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A: 0 - 158 (UniProt: P0A017)
PDB | External Database | Details |
---|---|---|
Leu 159 | - | expression tag |
Val 160 | - | expression tag |
Pro 161 | - | expression tag |
Arg 162 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18742.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1462.2 | |
All* | Total formula weight | 20204.7 |