6PQO
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, B, C | Transient receptor potential cation channel subfamily A member 1 | polymer | 1152 | 131495.5 | 4 | UniProt (O75762) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (Human) | Ankyrin-like with transmembrane domains protein 1,Transformation-sensitive protein p120 |
2 | E, F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
3 | C, D, A, B | 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide | non-polymer | 354.9 | 4 | Chemie (JT0) | |||
4 | C, D, A, B | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 8 | Chemie (LBN) | |||
5 | B, C, D, A | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 16 | Chemie (6OU) |
Sequence modifications
D, A, B, C: 2 - 1119 (UniProt: O75762)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
Ala 1 | - | expression tag |
Ser 1120 | - | expression tag |
Asn 1121 | - | expression tag |
Ser 1122 | - | expression tag |
Leu 1123 | - | expression tag |
Glu 1124 | - | expression tag |
Val 1125 | - | expression tag |
Leu 1126 | - | expression tag |
Phe 1127 | - | expression tag |
Gln 1128 | - | expression tag |
Gly 1129 | - | expression tag |
Pro 1130 | - | expression tag |
Ala 1131 | - | expression tag |
Ala 1132 | - | expression tag |
Asp 1133 | - | expression tag |
Tyr 1134 | - | expression tag |
Lys 1135 | - | expression tag |
Asp 1136 | - | expression tag |
Asp 1137 | - | expression tag |
Asp 1138 | - | expression tag |
Asp 1139 | - | expression tag |
Lys 1140 | - | expression tag |
Ala 1141 | - | expression tag |
His 1142 | - | expression tag |
His 1143 | - | expression tag |
His 1144 | - | expression tag |
His 1145 | - | expression tag |
His 1146 | - | expression tag |
His 1147 | - | expression tag |
His 1148 | - | expression tag |
His 1149 | - | expression tag |
His 1150 | - | expression tag |
His 1151 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 525982.2 | |
Branched | Number of molecules | 4 |
Total formula weight | 1697.6 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 18988.0 | |
All* | Total formula weight | 546667.7 |