6PP4
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-3-ylmethoxy)phenyl)-4-methylquinolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nitric oxide synthase, endothelial | polymer | 440 | 49345.8 | 4 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (Human) | Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII |
| 2 | CA, E, M, V (D, A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | DA, F, N, W (D, A, B, C) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 4 | Chemie (H4B) | |||
| 4 | FA, G, GA, I, P... (D, A, B, C) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 8 | Chemie (BTB) | |||
| 5 | EA, H, O, X (D, A, B, C) | 7-{3-(aminomethyl)-4-[(pyridin-3-yl)methoxy]phenyl}-4-methylquinolin-2-amine | non-polymer | 370.4 | 4 | Chemie (OUS) | |||
| 6 | J, Z (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | AA, K (C, A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | BA, IA, L, R (C, D, A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 9 | HA, S, U (D, B, C) | GADOLINIUM ATOM | non-polymer | 157.3 | 3 | Chemie (GD) | |||
| 10 | JA, KA, LA, MA (A, B, C, D) | water | water | 18.0 | 548 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 41 - 480 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 197383.1 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 7515.2 | |
| All* | Total formula weight | 204898.3 |
