6POU
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(4-(2-Aminoethyl)phenyl)-4-methylquinolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Nitric oxide synthase, endothelial | polymer | 440 | 49345.8 | 6 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (Human) | Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII |
| 2 | AA, CB, G, KA, Q... (C, F, A, D, B...) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 6 | Chemie (HEM) | |||
| 3 | BA, BB, CA, DB, EB... (C, F, A, D, B...) | 7-[4-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine | non-polymer | 277.4 | 12 | Chemie (M16) | |||
| 4 | DA, EA, FA, FB, GB... (C, F, A, D, B...) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 18 | Chemie (BTB) | |||
| 5 | AB, GA, IB, JA, L... (E, C, F, A, D...) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 6 | HB, IA, M, N, QA... (F, C, A, D, B) | GADOLINIUM ATOM | non-polymer | 157.3 | 8 | Chemie (GD) | |||
| 7 | HA, ZA (C, E) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | JB, KB, LB, MB, NB... (A, B, C, D, E...) | water | water | 18.0 | 858 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 41 - 480 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 296074.6 | |
| Non-Polymers* | Number of molecules | 55 |
| Total formula weight | 12824.5 | |
| All* | Total formula weight | 308899.1 |
