6PLG
Crystal structure of human PHGDH complexed with Compound 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | D-3-phosphoglycerate dehydrogenase | polymer | 314 | 33630.8 | 8 | UniProt (O43175) Pfam (PF00389) Pfam (PF02826) | Homo sapiens (Human) | 3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase |
| 2 | I, J, K, L, M... (A, B, C, D, E...) | (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid | non-polymer | 510.4 | 8 | Chemie (ONS) | |||
| 3 | N, P, R, T (E, F, G, H) | D-MALATE | non-polymer | 134.1 | 4 | Chemie (MLT) |
Sequence modifications
A, B, C, D, E, F, G, H: 4 - 315 (UniProt: O43175)
| PDB | External Database | Details |
|---|---|---|
| Ser 2 | - | expression tag |
| Met 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 269046.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4619.3 | |
| All* | Total formula weight | 273665.4 |
