6PKZ
Structure of human DNA polymerase beta N279A complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 335 | 38198.6 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (T) | DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4844.1 | 1 | synthetic construct | ||
| 3 | C (P) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') | polymer | 10 | 3085.0 | 1 | synthetic construct | ||
| 4 | D (D) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | synthetic construct | ||
| 5 | E, F (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | G (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | H (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine | non-polymer | 506.2 | 1 | Chemie (XG4) | |||
| 8 | I, J, K, L (A, T, P, D) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Ala 279 | Asn 279 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47663.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 576.5 | |
| All* | Total formula weight | 48240.3 |
