6PFD
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 60262.5 | 5 | UniProt (A0A0S4TER9) Pfam (PF00186) Pfam (PF00303) In PDB | Cryptosporidium hominis | |
2 | A, B, C, D, E | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
3 | A, B, C, D, E | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 326.2 | 5 | Chemie (UFP) | |||
4 | A, B, C, D, E | 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid | non-polymer | 447.4 | 5 | Chemie (OEJ) | |||
5 | A, B, C, D, E | METHOTREXATE | non-polymer | 454.4 | 5 | Chemie (MTX) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 301312.6 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 9867.2 | |
All* | Total formula weight | 311179.8 |